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Polesskaya Anna
PERSONNEL DE RECHERCHE

Contact

Office : 84:30-26
Telephone : +33169334871
Department/Laboratory/Direction : CA/DER/LAB/BIOC
Additional function :
MAITRE DE CONFÉRENCES

Biography and Current Works

Mission: 

Chargée de Recherche (CNRS), Laboratoire de Biochimie, UMR 7654, Ecole Polytechnique

Biography: 

POLESSKAYA Anna

Née le 09/02/1969

 

Diplômes acquis:

Thèse d’Université d’Etat de Moscou: le 24/12/1997

Habilitation à Diriger des Recherches (HDR), Université Paris-Sud XI: le 09/09/2008.

 

1986: Baccalauréat scientifique (mention très bien), Moscou, Russie.

 

1991: DEA (mention très bien), Centre Oncologique, Moscou, Russie.   Thème:Tumorigenesis and cytotoxic activity of T-lymphocytes.

 

1991-1993: Ingénieur d’études, Human Genome Project, Engelhardt Institutede Biologie Moleculaire, Moscou, Russie.

 

1993-1997: Thèse d’Université (Université d’Etat de Moscou, Russie). Thème: Action des toxines bacteriennes sur les cellules humaines.

 

1998-2001: Chercheur post-doctoral dans le groupe du Dr Annick Harel-Bellan, CNRS, Villejuif. Boursiere FEBS (Federation of European Biochemical Societies), puis ARC (Association pour la Recherche sur le Cancer). Thème: Régulation transcriptionelle de la différenciation musculaire.

 

2001-2003: Chercheur post-doctoral dans le groupe du Dr. Michael Rudnicki (OHRI, Ottawa, Canada). Boursiere MDA. Thème: Cellules souches dans le muscle squelettique.

 

2003-2006: Chercheur CNRS (CR2), UPR 9079, CNRS, Villejuif. Thème: Régulation transcriptionelle de la différenciation musculaire.

 

2007-2008: Chercheur CNRS (CR1), FRE 2944, CNRS, Villejuif. Thème: Régulation transcriptionelle et post-transcriptionnelle de la différenciation musculaire.

 

2008-2011: Chef d’équipe, chercheur CNRS (CR1), FRE 3377, CNRS, Villejuif. Thème: Régulation post-transcriptionnelle de l’expression des gènes.

 

2011-2014: Chef d’équipe, chercheur CNRS (CR1), FRE 3377, CEA, Saclay. Thème: Régulation post-transcriptionnelle de l’expression des gènes, prolifération et motilité cellulaire.

 

2014-2015: Chef d’équipe, chercheur CNRS (CR1), UMR 9198 (I2BC). Thème: Régulation post-transcriptionnelle de l’expression des gènes, prolifération et motilité cellulaire.

 

2016: Changement d’affectation, adresse actuelle: Laboratoire de Biochimie, Ecole Polytechnique, Palaiseau. Thème du projet: Régulation de l’expression des gènes, cytosquelette et motilité cellulaire.

 

Teaching: 

Maître de Conférences (40%), Departement de Biologie, Ecole Polytechnique

Research: 

Résumé d’activité scientifique et d’encadrement des étudiants

Publications (PubMed):                                                       34

Présentations orales et sur invitation:                                  27

Etudiant(e)s en thèse encadré(e)s:                                        6

Thèses soutenues sous ma direction:                                   4

Participation dans des jurys de thèses:                                17

 

Main Publications and Links

Publications: 

1: Deforzh E, Vargas TR, Kropp J, Vandamme M, Pinna G, Polesskaya A. IMP-3

protects the mRNAs of cyclins D1 and D3 from GW182/AGO2-dependent translational

repression. Int J Oncol. 2016 Dec;49(6):2578-2588.

 

2: Polesskaya A, Pinna G, Sassi Y, Vandamme M, Bigot A, Mouly V, Morozova N,

Harel-Bellan A, Degerny C. Post-transcriptional modulation of interleukin 8 by

CNOT6L regulates skeletal muscle differentiation. Biochim Biophys Acta. 2015 Dec

1;1863(2):263-270.

 

3: Portilho DM, Alves MR, Kratassiouk G, Roche S, Magdinier F, de Santana EC,

Polesskaya A, Harel-Bellan A, Mouly V, Savino W, Butler-Browne G, Dumonceaux J.

miRNA expression in control and FSHD fetal human muscle biopsies. PLoS One. 2015

Feb 18;10(2)

 

4: Meyer SU, Thirion C, Polesskaya A, Bauersachs S, Kaiser S, Krause S, Pfaffl

MW. TNF-α and IGF1 modify the microRNA signature in skeletal muscle cell

differentiation. Cell Commun Signal. 2015 Jan 29;13:4.

 

5: Kropp J, Degerny C, Morozova N, Pontis J, Harel-Bellan A, Polesskaya A. miR-98 delays skeletal muscle differentiation by down-regulating E2F5. Biochem J. 2015 Feb 15;466(1):85-93.

 

6: Boudoukha S, Rivera Vargas T, Dang I, Kropp J, Cuvellier S, Gautreau A,

Polesskaya A. MiRNA let-7g regulates skeletal myoblast motility via Pinch-2. FEBS Lett. 2014 May 2;588(9):1623-9.

 

7: Vislovukh A, Vargas TR, Polesskaya A, Groisman I. Role of 3'-untranslated

region translational control in cancer development, diagnostics and treatment.

World J Biol Chem. 2014 Feb 26;5(1):40-57.

 

8: Polesskaya A, Degerny C, Pinna G, Maury Y, Kratassiouk G, Mouly V, Morozova N, Kropp J, Frandsen N, Harel-Bellan A. Genome-wide exploration of miRNA function in mammalian muscle cell differentiation. PLoS One. 2013 Aug 21;8(8)

 

9: Rivera Vargas T, Boudoukha S, Simon A, Souidi M, Cuvellier S, Pinna G,

Polesskaya A. Post-transcriptional regulation of cyclins D1, D3 and G1 and

proliferation of human cancer cells depend on IMP-3 nuclear localization.

Oncogene. 2014 May 29;33(22)

 

10: Dmitriev P, Barat A, Polesskaya A, O'Connell MJ, Robert T, Dessen P, Walsh TA, Lazar V, Turki A, Carnac G, Laoudj-Chenivesse D, Lipinski M, Vassetzky YS.

Simultaneous miRNA and mRNA transcriptome profiling of human myoblasts reveals a

novel set of myogenic differentiation-associated miRNAs and their target genes.

BMC Genomics. 2013 Apr 18;14:265.

 

11: Charrin S, Latil M, Soave S, Polesskaya A, Chrétien F, Boucheix C, Rubinstein E. Normal muscle regeneration requires tight control of muscle cell fusion by tetraspanins CD9 and CD81. Nat Commun. 2013;4:1674.

 

12: Silva VA, Polesskaya A, Sousa TA, Corrêa VM, André ND, Reis RI, Kettelhut IC, Harel-Bellan A, De Lucca FL. Expression and cellular localization of microRNA-29b and RAX, an activator of the RNA-dependent protein kinase (PKR), in the retina of streptozotocin-induced diabetic rats. Mol Vis. 2011;17:2228-40.

 

13: Harel-Bellan A, Ameyar M, Polesskaya A, Degerny C. [Small non-coding RNAs:

new targets and new therapeutic possibilities]. Bull Acad Natl Med. 2010

Feb;194(2):319-24; discussion 324-5. French.

 

14: Boudoukha S, Cuvellier S, Polesskaya A. Role of the RNA-binding protein IMP-2 in muscle cell motility. Mol Cell Biol. 2010 Dec;30(24):5710-25.

 

15: Yahi H, Fritsch L, Philipot O, Guasconi V, Souidi M, Robin P, Polesskaya A,

Losson R, Harel-Bellan A, Ait-Si-Ali S. Differential cooperation between

heterochromatin protein HP1 isoforms and MyoD in myoblasts. J Biol Chem. 2008 Aug 29;283(35):23692-700.

 

16: Naguibneva I, Polesskaya A, Ameyar-Zazoua M, Souidi M, Groisman R, Cuvellier

S, Ait-Si-Ali S, Pritchard LL, Harel-Bellan A. [Micro-RNAs and muscle

differentiation]. J Soc Biol. 2007;201(4):367-76.

 

17: Polesskaya A, Harel-Bellan A. [A novel role for an embryonic regulatory

protein Lin-28 in adult skeletal muscle differentiation]. Med Sci (Paris). 2007

Oct;23(10):796-7. French.

 

18: Polesskaya A, Cuvellier S, Naguibneva I, Duquet A, Moss EG, Harel-Bellan A.

Lin-28 binds IGF-2 mRNA and participates in skeletal myogenesis by increasing

translation efficiency. Genes Dev. 2007 May 1;21(9):1125-38.

 

19: Kurmanova A, Llorente A, Polesskaya A, Garred O, Olsnes S, Kozlov J, Sandvig

K. Structural requirements for furin-induced cleavage and activation of Shiga

toxin. Biochem Biophys Res Commun. 2007 May 25;357(1):144-9.

 

20: Duquet A, Polesskaya A, Cuvellier S, Ait-Si-Ali S, Héry P, Pritchard LL,

Gerard M, Harel-Bellan A. Acetylation is important for MyoD function in adult

mice. EMBO Rep. 2006 Nov;7(11):1140-6

 

21: Naguibneva I, Ameyar-Zazoua M, Nonne N, Polesskaya A, Ait-Si-Ali S, Groisman

R, Souidi M, Pritchard LL, Harel-Bellan A. An LNA-based loss-of-function assay

for micro-RNAs. Biomed Pharmacother. 2006 Nov;60(9):633-8.

 

22: Naguibneva I, Ameyar-Zazoua M, Polesskaya A, Ait-Si-Ali S, Groisman R, Souidi M, Cuvellier S, Harel-Bellan A. The microRNA miR-181 targets the homeobox protein Hox-A11 during mammalian myoblast differentiation. Nat Cell Biol. 2006

Mar;8(3):278-84.

 

23: Ait-Si-Ali S, Guasconi V, Fritsch L, Yahi H, Sekhri R, Naguibneva I, Robin P, Cabon F, Polesskaya A, Harel-Bellan A. A Suv39h-dependent mechanism for silencing S-phase genes in differentiating but not in cycling cells. EMBO J. 2004 Feb 11;23(3):605-15. Epub 2004 Feb 5.

 

24: Seale P, Polesskaya A, Rudnicki MA. Adult stem cell specification by Wnt

signaling in muscle regeneration. Cell Cycle. 2003 Sep-Oct;2(5):418-9. Review.

 

25: Polesskaya A, Seale P, Rudnicki MA. Wnt signaling induces the myogenic

specification of resident CD45+ adult stem cells during muscle regeneration.

Cell. 2003 Jun 27;113(7):841-52.

 

26: Polesskaya A, Rudnicki MA. A MyoD-dependent differentiation checkpoint:

ensuring genome integrity. Dev Cell. 2002 Dec;3(6):757-8. Review.

 

27: Polesskaya A, Naguibneva I, Fritsch L, Duquet A, Ait-Si-Ali S, Robin P,

Vervisch A, Pritchard LL, Cole P, Harel-Bellan A. CBP/p300 and muscle

differentiation: no HAT, no muscle. EMBO J. 2001 Dec 3;20(23):6816-25.

 

28: Polesskaya A, Harel-Bellan A. Acetylation of MyoD by p300 requires more than

its histone acetyltransferase domain. J Biol Chem. 2001 Nov 30;276(48):44502-3.

Epub 2001 Sep 27.

 

29: Polesskaya A, Naguibneva I, Duquet A, Bengal E, Robin P, Harel-Bellan A.

Interaction between acetylated MyoD and the bromodomain of CBP and/or p300. Mol

Cell Biol. 2001 Aug;21(16):5312-20.

 

30: Timmermann S, Lehrmann H, Polesskaya A, Harel-Bellan A. Histone acetylation

and disease. Cell Mol Life Sci. 2001 May;58(5-6):728-36. Review.

 

31: Polesskaya A, Duquet A, Naguibneva I, Weise C, Vervisch A, Bengal E, Hucho F, Robin P, Harel-Bellan A. CREB-binding protein/p300 activates MyoD by acetylation. J Biol Chem. 2000 Nov 3;275(44):34359-64.

 

32: Ait-Si-Ali S, Polesskaya A, Filleur S, Ferreira R, Duquet A, Robin P, Vervish A, Trouche D, Cabon F, Harel-Bellan A. CBP/p300 histone acetyl-transferase activity is important for the G1/S transition. Oncogene. 2000 May

11;19(20):2430-7.

 

33: Garred O, Dubinina E, Polesskaya A, Olsnes S, Kozlov J, Sandvig K. Role of

the disulfide bond in Shiga toxin A-chain for toxin entry into cells. J Biol

Chem. 1997 Apr 25;272(17):11414-9.

 

34: Kronin VV, Anosova NG, Popov IA, Polesskaya AN, Brondz BD, Krivoshein YS.

Intravenous injection of allogeneic cells can prime T-lymphocytes with cytotoxic

activity. Immunol Lett. 1993 Jan;35(1):13-8.

 

HAL Publications: 
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