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Onglets principaux

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Chapat Clément
PERSONNEL DE RECHERCHE

Contact

Bureau : 84:30-20
Téléphone : +33169334890
Département/Laboratoire/Service : CA/DER/LAB/BIOC

Bibliographie & travail en cours

Mission: 

Chargé de Recherche CNRS

Biographie: 

2014: Postdoctoral fellow in Biochemistry. Department of biochemistry - McGill University.

2013: PhD in Cellular and Molecular Biology. University of Lyon.

2010: Certificate of animal experimentation (level 1). Claude Bernard University - Lyon1 (UCBL).

2009: Master’s Degree in Biosciences. Ecole Normale Supérieure de Lyon.

2007: Bachelor’s degree in Cellular and Molecular Biology and Oncology. Ecole Normale Supérieure de Lyon.

Publications et Liens

Publications: 

- Jafarnejad SM#, Chapat C#, Matta-Camacho E, Gelbart IA, Hesketh GG, Arguello M, Garzia A, Kim SH, Attig J, Shapiro M, Morita M, Khoutorsky A, Alain T, Gkogkas CG, Stern-Ginossar N, Tuschl T, Gingras AC, Duchaine TF, Sonenberg N. Translational control of ERK signaling through miRNA/4EHP-directed silencing. Elife. 2018 Feb 7;7. pii: e35034. doi: 10.7554 (#co-premiers auteurs)

 

- Garzia A, Jafarnejad SM, Meyer C, Chapat C, Gogakos T, Morozov P, Amiri M, Shapiro M, Molina H, Tuschl T, Sonenberg N. The E3 ubiquitin ligase and RNA-binding protein ZNF598 orchestrates ribosome quality control of premature polyadenylated mRNAs. Nature Communications. 2017;8:16056.

 

- Chapat C*, Chettab K, Simonet P, Wang P, De La Grange P, Le Romancer M, Corbo L. Alternative splicing of CNOT7 diversifies CCR4-NOT functions.  Nucleic Acids Research. 2017 Aug 21;45 (14):8508-8523. (*auteur correspondant)

 

- Gantois I, Khoutorsky A, Popic J, Aguilar-Valles A, Freemantle E, Cao R, Sharma V, Pooters T, Nagpal A, Skalecka A, Truong VT, Wiebe S, Groves IA, Jafarnejad SM, Chapat C, McCullagh EA, Gamache K, Nader K, Lacaille JC, Gkogkas CG, Sonenberg N. Metformin ameliorates core deficits in a mouse model of fragile X syndrome. Nature Medicine. 2017 Jun;23 (6):674-677.

 

- Chapat C#, Jafarnejad SM#, Matta-Camacho E, Hesketh GG, Gelbart IA, Attig J, Gkogkas CG, Alain T, Stern-Ginossar N, Fabian MR, Gingras AC, Duchaine TF, Sonenberg N. Cap-binding protein 4EHP effects translation silencing by microRNAs.  Proc Natl Acad Sci USA. 2017 May 23;114(21):5425-5430. (#co-premiers auteurs)

 

- Wu E, Vashisht AA, Chapat C, Flamand MN, Cohen E, Sarov M, Tabach Y, Sonenberg N, Wohlschlegel J, Duchaine TF. A continuum of mRNP complexes in embryonic microRNA-mediated silencing. Nucleic Acids Research. 2017 Feb 28;45(4):2081-2098.

 

- Chapat C and Corbo L. Novel roles of the CCR4-NOT complex. Wiley Interdiscip Rev RNA. 2014 Nov-Dec;5(6):883-901.

 

- Chapat C#, Kolytcheff C#, Le Romancer M, Auboeuf D, De La Grange P, Chettab K, Sentis S and Corbo L. hCAF1 regulates interferon signaling by targeting STAT1. 2013. The EMBO Journal. 2013 Feb 5. doi: 10.1038 (#co-premiers auteurs)

 

- Chapat C, Kolytcheff C, De la Grange P, Auboeuf D, Sentis S and Corbo L. hCAF1: a new key in the interferon signalling in MCF7 breast cancer cell line. Bulletin Du Cancer. 2011. Volume: 98 (résumé de poster)

 

- Perrard MH, Vigier M, Damestoy A, Chapat C, Silandre D, Rudkin BB, Durand P. Beta-Nerve growth factor participates in an auto/paracrine pathway of regulation of the meiotic differentiation of rat spermatocytes. 2007. Journal of Cellular Physiology 210(1) 51-62.

 

Publications HAL: 
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Hal

Publications HAL: 

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