Séminaire Département de Biologie - Dr Christian NERI
le 15 novembre à 11 h en Amphi Carnot
Dr. Christian NERI, IBPS, Paris
How does the brain respond to Huntington's disease? Insights from systems modelling into adaptation
Neurodegenerative diseases are strongly associated to the production of misfolded proteins (proteotoxicity) and the consequences of proteotoxic stress on brain homeostasis and activity. Understanding how the brain can resist to neurodegenerative disease and maintain function is an active area of research that has strong therapeutic potential. The response of the brain to neurodegenerative diseases such as Huntington's disease (HD) can be viewed as a biological program prescribing the system dynamics, governed by remodeling of a network of genetic interactions in response to HD and age. The problem is to extract the rules that govern the molecular and cellular dynamics of HD in such ways that precise testable hypotheses can be generated for subsequent evaluation in biological models of the disease. The solution that we have developed to this problem is to employ network methods for generating and cross-integrating HD networks. Network analysis of a large amount of HD data highlights a model in which several waves of molecular adaptation may underlie the dynamic of HD, involving specific synaptic homeostasis and cell survival pathways.
Lieu(x) : Ecole Polytechnique, Amphithéâtre Carnot
Contact : Yves Mechulam