Séminaire départemental Dr. Evgeny V. DENISOV

vendredi 22 Septembre 10h00 , en Amphithéâtre LAGARRIGUE

Dr. Evgeny V. DENISOV, 
(Tomsk Cancer Research Center/Tomsk State University, Russian Federation)

Intratumoral heterogeneity is a common phenomenon in most human cancers. During the last years, intratumoral heterogeneity became one of the hottest topics of modern oncology, because of its crucial role in therapy resistance and prognosis, emphasizing the need to develop methods to analyse this diversity in cancer biopsies. We focused our work on breast cancer,  where tumors display tubular, alveolar, solid, trabecular, and discrete morphological structures, which can be analyzed by laser-assisted microdissection. The structures are composed of transcriptionally distinct tumor cell populations with various degrees of epithelial-mesenchymal transition and stemness. Through differential expression of genes encoding drug resistance, cancer invasion and and various factors promoting the premetastatic niche, these various morphological stuctures are prognostic factors associated with metastasis formation and predict the  chemotherapy response of breast cancers.

Selected publications:
Gerashchenko T.S., Zavyalova M.V., Denisov E.V., Krakhmal N.V., Pautova D.N., Cherdyntseva N.V., Perelmuter V.M. Intratumoral morphological heterogeneity in breast cancer as a reflection of metastatic potential and tumor chemosensitivity. Acta Naturae 2017, in press.
Denisov E.V., Skryabin N.A., Gerashchenko T.S., Tashireva L.A., Wilhelm J., Buldakov M.A., Sleptcov A.A., Lebedev I.N., Vtorushin S.V., Zavyalova M.V., Cherdyntseva N.V., Perelmuter V.M. Clinically relevant morphological structures in breast cancer represent transcriptionally distinct tumor cell populations with varied degrees of epithelial-mesenchymal transition and CD44+CD24- stemness. Oncotarget 2017,8:61163-61180.
Tashireva L.A., Denisov E.V., Gerashchenko T.S., Pautova D.N., Buldakov M.A., Zavyalova M.V., Kzhyshkowska J., Cherdyntseva N.V., Perelmuter V.M. Intratumoral heterogeneity of macrophages and fibroblasts in breast cancer is associated with the morphological diversity of tumor cells and contributes to lymph node metastasis. Immunobiology 2017,222:631-640.
Denisov E.V., Litviakov N.V., Zavyalova M.V., Perelmuter V.M., Vtorushin S.V., Tsyganov M.M., Gerashchenko T.S., Garbukov E.Y., Slonimskaya E.M., Cherdyntseva N.V. Intratumoral morphological heterogeneity of breast cancer: neoadjuvant chemotherapy efficiency and multidrug resistance gene expression. Sci Rep 2014,4:4709.
Gerashchenko T.S., Denisov E.V., Litviakov N.V., Zavyalova M.V., Vtorushin S.V., Tsyganov M.M., Perelmuter V.M., Cherdyntseva N.V. Intratumor heterogeneity: nature and biological significance. Biochemistry (Mosc) 2013,78:1201-1215.

Lieu(x) : Ecole Polytechnique, Amphithéâtre LAGARRIGUE